In CVD-free individuals, risk of diabetes increases with elevated blood pressure

7-10-2015 • Emdin CA et al., J Am Coll Cardiol. 2015
Risk of new onset diabetes increased with higher SBP and DBP. Relative risk increase was lower in older people and those with BMI>35, but absolute risk remained substantial in those individuals. Read more
News • 29-9-2015 • Prague, Sept 17-18, 2015

Lively debate at annual EPCCS Clinical Masterclass to yield practical guidance

This year’s EPCCS Meeting dedicated much time to discussion and identifying gaps in the evidence, aimed at composing practical recommendations for CV risk management in general practice. Read more

The role of nonstatin lipid-modifying agents in CV risk management

28-9-2015 • Hegele RA et al., ATVB 2015
Recent data show that similar CV benefits can be achieved with nonstatin agents, as with statins, suggesting that pleiotropic effects of statins are not central to their effects. Read more
News • 7-9-2015

New heart failure agent also beneficial at systolic hypertension and arterial stiffness

ESC 2015 LCZ696 lowers central blood pressure and pulse pressure more effectively than an angiotensin receptor blocker in a high-risk population with systolic hypertension and increased pulse pressure. Read more
News • 5-9-2015

Spironolactone most effective treatment for resistant hypertension

ESC 2015 In patients with resistant hypertension, addition of the diuretic spironolactone was significantly more effective than adding other BP-lowering drugs, according to results of the PATHWAY-2 trial. Read more

Self-injectable PCSK9 antibody well accepted by patients and prescribers

24-8-2015 • Roth EM et al., Clin Ther. 2015
Willingness of patients to self-inject and of physicians to prescribe alirocumab using a prefilled pen or syringe was high. Specialists estimated acceptance by patients higher than primary care physicians. Read more

Risk prediction with SCORE model not improved by addition HDL-C

6-10-2015 • Mortensen MB et al., Eur Heart J 2015
The newly recommended SCORE-HDL model did not improve discrimination between cases and non-cases in a ‘low-risk’ country, and both models overestimate risk of fatal CVD in this population. Read more
News • 28-9-2015

Next step on the way to approval of first antidote to anticoagulant effect of NOAC

Following accelerated assessment, EMAs CHMP recommends granting a marketing authorisation for idarucizumab, a reversal agent for dabigatran, given its potential to respond to an unmet medical need. Read more

Glucose-lowering agent shows CV benefit in outcome trial, for the first time

21-9-2015 • Zinman B et al., NEJM 2015
Treatment with SGLT2 inhibitor empagliflozin in addition to standard care reduces CV mortality, nonfatal MI and stroke in T2DM patients at high CV risk, shows the EMPA-REG OUTCOME trial. Read more
News • 7-9-2015

Using two common diuretics at half dose is effective without undesired side effects

ESC 2015 The combination of amiloride and hydrochlorothiazide, each at half dose, can significantly reduce BP without the side-effects caused by full doses of either alone, the PATHWAY 3 study showed. Read more
News • 26-8-2015

E-health vital to beat CV disease, says ESC

European Society of Cardiology position paper outlines how the ESC will exploit e-health, the use of ICT in healthcare services, in education and research, while tackling issues of quality control and data security. Read more

More CV health risks with industrial trans fats than with saturated fats

23-8-2015 • De Souza RJ et al., BMJ 2015
Meta-analysis of the association between fat intake and CV health reports higher CV morbidity and mortality with increased trans fat intake (mostly industrially produced), but not with saturated fats. Read more

Upcoming meetings

Meeting reports & resources

EPCCS Guidance Documents Evidence- and meeting-based guidance for primary care
EPCCS 2015 Report of 8th Annual EPCCS meeting held in Prague.
EPCCS 2014 Report of 7th Annual EPCCS meeting held in Brussels.
EPCCS 2013 Report of 6th Annual EPCCS meeting held in London
All meeting reports...