Different risks of HF, CVD, and mortality associated with use of different antidiabetic drugs

24-8-2016 • Hippisley-Cox J, et al. BMJ 2016
In an open cohort study of 469 688 diabetic patients in 1243 UK primary care practices, clinically relevant differences between diabetes drugs and the risk for heart failure, cardiovascular disease, and all-cause mortality were observed. Read more

To screen or not to screen for FH in childhood

18-8-2016 • Lozano et al., JAMA 2016
Identification of and lipid-lowering treatment of familial hypercholesterolemia in childhood reduces lipid concentrations in the short term, with little evidence of harm. Long-term evidence is lacking. Read more

Cognitive function in elderly patients at CV risk affected by LDL-c variability

8-8-2016 • Smit RAJ et al., Circulation 2016
In elderly PROSPER study patients at high CV risk, a high variability of LDL-c levels was associated with lower cognitive scores, based on 4 cognitive tests. Read more

Whole grain consumption associated with lower mortality risk

7-7-2016 • Zong G et al., Circulation 2016
In a meta-analysis of 786,076 individuals, the consumption of whole grain products was inversely and significantly associated with mortality, especially CVD mortality, in a dose-response manner. Read more

Visit-to-visit variability in blood pressure associated with cognitive decline

4-7-2016 • Qin B et al., Hypertension 2016
In contrast to mean values, the variability in SBP and DBP between visits was associated with cognitive and verbal decline. Read more

Many AF patients inappropriately on aspirin monotherapy rather than on anticoagulation

1-7-2016 • Hsu JH et al., J Am Coll Cardiol 2016
Approximately one third of AF outpatients at moderate to high risk for stroke treated by a cardiovascular specialist, received aspirin monotherapy, in spite of the lack of data supporting this practice. Read more

Real-world safety data show differences between anticoagulants in AF patients

23-8-2016 • Lip GYH et al., Thromb Haemost 2016
In a real-world observational study using propensity score matched cohorts, apixaban initiation was associated with significantly lower risk of major bleeding compared to warfarin and rivaroxaban. Read more

Harmful effect of prolonged sitting can be eliminated if active enough, on a daily basis

11-8-2016 • Ekeland et al., The Lancet 2016
A harmonised meta-analysis of data of over 1 million individuals shows that more daily physical activity (60-75 min) than recommended by guidelines cancels out mortality effect of long sitting time (>8h). Read more

No evidence for superiority of gliclazide over other sulphonylureas in reducing hypoglycaemia in general practice

18-7-2016 • van Dalem J et al., BMJ. 2016
In GPRD data, current use of sulphonylureas only (with active or inactive metabolites) was associated with an increased risk of hypoglycaemic events, as compared with current use of metformin. Read more

New heart failure type-specific risk prediction models

5-7-2016 • Ho JE et al., Circ Heart Fail. 2016
Separate risk prediction models for heart failure with preserved and reduced ejection fraction were developed and validated that may facilitate targeted treatment strategies in the future. Read more

More people quit taking statins soon after media debates on their side-effects

4-7-2016 • Matthews A et al., BMJ 2016
In the 6 months following an intense media coverage of adverse effects of statins, more patients discontinued statin therapy, prescribed as primary or secondary prevention in UK primary care. Read more

Using 5 or more drugs concomitantly increases risk for comorbidity and complications in AF

29-6-2016 • Jaspers Focks J et al., BMJ 2016
In the ARISTOTLE trial population, polypharmacy was common and associated with higher comorbidity, mortality, and higher event rates of thromboembolic complications and major bleeding. Read more

Upcoming meetings

Meeting reports & resources

EPCCS 2017 Report of the Cardiovascular Summit held in Dublin, Ireland
EPCCS Guidance Documents Evidence- and meeting-based guidance for primary care
EPCCS 2015 Report of 8th Annual EPCCS meeting held in Prague.
EPCCS 2014 Report of 7th Annual EPCCS meeting held in Brussels.
All meeting reports...