News • 5-9-2016
Study on long term exposure to low LDL-c and low SBP suggests that most CV events are preventable
Exposure to low levels of LDL-c and SBP have independent, multiplicative and cumulative causal effects on CV risk, according to a Mendelian randomisation study.
News • 4-9-2016
CPAP did not lower CV events in patients with obstructive sleep apnea
Coronary or cerebrovascular patients with obstructive sleep apnea did not show improvement in CV mortality with CPAP therapy, but there was a trend towards fewer cerebrovascular events and better mood.
Different risks of HF, CVD, and mortality associated with use of different antidiabetic drugs
24-8-2016 • Hippisley-Cox J, et al. BMJ 2016
In an open cohort study of 469 688 diabetic patients in 1243 UK primary care practices, clinically relevant differences between diabetes drugs and the risk for heart failure, cardiovascular disease, and all-cause mortality were observed.
To screen or not to screen for FH in childhood
18-8-2016 • Lozano et al., JAMA 2016
Identification of and lipid-lowering treatment of familial hypercholesterolemia in childhood reduces lipid concentrations in the short term, with little evidence of harm. Long-term evidence is lacking.
Cognitive function in elderly patients at CV risk affected by LDL-c variability
8-8-2016 • Smit RAJ et al., Circulation 2016
In elderly PROSPER study patients at high CV risk, a high variability of LDL-c levels was associated with lower cognitive scores, based on 4 cognitive tests.
Whole grain consumption associated with lower mortality risk
7-7-2016 • Zong G et al., Circulation 2016
In a meta-analysis of 786,076 individuals, the consumption of whole grain products was inversely and significantly associated with mortality, especially CVD mortality, in a dose-response manner.
News • 4-9-2016
Weekly remote monitoring of CIED in heart failure does not yield benefit
In the REM-HF study, weekly remote monitoring of CIED did not affect mortality or hospitalization for HF, in comparison with standard therapy.
News • 4-9-2016
Remote monitoring CRT reduces clinic visits, without clinical benefit
Remote monitoring of a CRT in HF patients did not result in clinical benefit in the MORE-CARE study, but a reduction of clinic visits yielded a cost saving.
Real-world safety data show differences between anticoagulants in AF patients
23-8-2016 • Lip GYH et al., Thromb Haemost 2016
In a real-world observational study using propensity score matched cohorts, apixaban initiation was associated with significantly lower risk of major bleeding compared to warfarin and rivaroxaban.
Harmful effect of prolonged sitting can be eliminated if active enough, on a daily basis
11-8-2016 • Ekeland et al., The Lancet 2016
A harmonised meta-analysis of data of over 1 million individuals shows that more daily physical activity (60-75 min) than recommended by guidelines cancels out mortality effect of long sitting time (>8h).
No evidence for superiority of gliclazide over other sulphonylureas in reducing hypoglycaemia in general practice
18-7-2016 • van Dalem J et al., BMJ. 2016
In GPRD data, current use of sulphonylureas only (with active or inactive metabolites) was associated with an increased risk of hypoglycaemic events, as compared with current use of metformin.
New heart failure type-specific risk prediction models
5-7-2016 • Ho JE et al., Circ Heart Fail. 2016
Separate risk prediction models for heart failure with preserved and reduced ejection fraction were developed and validated that may facilitate targeted treatment strategies in the future.
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