Gastrointestinal safety profiles differ among direct oral anticoagulants

28-3-2017 • Abraham NS, et al, Gastroenterology 2017
In a large population-based cohort of AF patients on DOACs, apixaban had most favourable gastrointestinal safety profile among all age groups, and rivaroxaban the least favourable.  Read more

Triglyceride plus HDL-C level identifies subpopulations at increased risk of CHD or stroke

27-3-2017 • Lee JS, et al, Diabetes Care 2017
High fasting triglyceride levels plus low HDL-C levels were associated with increased risks of incident CHD and ischaemic stroke, particularly in diabetic patients and those with LDL-C ≥130 mg/dL. Read more

More arterial stiffness in heavy alcohol consumers

2-3-2017 • O’Neill D, et al, JAHA, 2017
Using alcohol consumption data of 25 years, it was found that especially male heavy drinkers have increased arterial stiffness, and over time, pulse wave velocity of non-drinkers increased most.  Read more

E-cigarette use may not be harmless

1-3-2017 • Moheimani RS, et al, JAMA Cardiol, 2017
Habitual e-cigarette use was associated with a shift in cardiac autonomic balance toward sympathetic predominance and increased oxidative stress, both associated with increased CV risk.  Read more

Reduced doses NOAC show similar efficacy and bleeding risk but possibly higher mortality risk

20-2-2017 • Nielsen PB et al., BMJ. 2017
Real-world data show lower dose NOACs associated with similar risk of thromboembolic events and similar or lower rates of bleeding as compared with warfarin in AF, but mortality risk seems higher with NOACs. Read more

Functions of HDL particles better with Mediterranean diet

16-2-2017 • Hernáez Á, et al.
In a subgroup of PREDIMED study patients it was shown that a Mediterranean diet, especially the one enriched with olive oil, improved biological functions of HDL particles.  Read more
News • 28-3-2017

EPCCS Practical Guidance on Heart Failure Diagnosis and Management in Primary Care

Based on the Heart Failure session and discussion during the 8th EPCCS Annual Meeting in Prague, this guidance document was written to help physicians diagnose and manage heart failure in their primary care practice. Read more

Physical activity and BMI show dose-response association with risk of heart failure

13-3-2017 • Pandey A J Am Coll Cardiol. 2017
In a pooled analysis of individual-level data from 3 prospective studies, a dose–response association between physical activity, BMI, and risk of HF was observed, particularly in HFpEF patients. Read more

Preterm delivery associated to maternal CVD risk

1-3-2017 • Tanz LJ, et al, Circulation, 2017
Preterm delivery is independently predictive of CVD which is only partially explained by postpartum development of traditional CVD risk factors.  Read more

57% decrease in ischaemic stroke incidence by changing risk factors

21-2-2017 • Vangen-Lønne AM, et al, Stroke, 2017
In an analysis from data between 1995 to 2012, changes in risk factors accounted for 57% of the decreased IS incidence and most important contributors were decline in SBP and prevalence of smoking. Read more

Strict BP control did not improve or worsen gait speed in elderly SPRINT participants

20-2-2017 • Gilstrap LG et al., J Am Heart Assoc. 2017
No differences in gait speed decline or mobility limitations were seen in individuals of 75 years and older were seen between those receiving intensive BP-lowering therapy vs. standard therapy. Read more

Healthy relatives of CAD patients have high coronary plaque burden

15-2-2017 • Christiansen MK et al. JACC Cardiol Img 2017
CT angiograms in 88 healthy relatives of patients with CAD onset before the age of 40, displayed high plaque burden and more unfavourable plaque features compared to controls. Read more

Upcoming meetings

Meeting reports & resources

EPCCS Guidance Documents Evidence- and meeting-based guidance for primary care
EPCCS 2015 Report of 8th Annual EPCCS meeting held in Prague.
EPCCS 2014 Report of 7th Annual EPCCS meeting held in Brussels.
EPCCS 2013 Report of 6th Annual EPCCS meeting held in London
All meeting reports...