Polypharmacy in patients with AF can increase bleeding risk

2-2-2016 • Piccini JP et al., Circulation 2016
The risk of major bleeding with rivaroxaban compared with warfarin was reduced in patients in ROCKET-AF taking fewer than 5 medications, but not in patients taking 5 or more medications, whereas the risk of stroke was not influenced by multiple medications. Read more

Prediction of readmissions of heart failure patients not improved by self-reported risk factors

27-1-2016 • Krumholz HM et al. J Am Coll Cardiol HF 2016
Self-reported socioeconomic, health status, adherence, and psychosocial variables, on top of traditional demographic and clinical variables, failed to improve the predictive accuracy of readmission risk for patients with heart failure. Read more

Reason to question guideline recommendations regarding sodium restriction in HF patients

25-1-2016 • Doukky R et al., J Am Coll Cardiol HF 2016
In patients with chronic heart failure, low dietary sodium intake (<2,500 mg/d) was associated with increased risk of heart failure hospitalisation. Read more

Selective heart rate slowing worsens exercise capacity in HFpEF patients

16-1-2016 • Pal N et al., Circulation. 2015
Heart rate reduction with ivabradine had a detrimental effect on peak oxygen uptake and on submaximal exercise capacity in patients with heart failure with preserved ejection fraction Read more

Preventing ASCVD events: which risk assessment strategy to initiate primary prevention is best?

11-1-2016 • Mortensen MB et al., JACC 2015
Clinical performance of risk-based approach for treatment eligibility as primary prevention was better than trial-based or hybrid approaches, while treating fewer individuals. Read more

High risk elderly AF patients benefit from good quality anticoagulation control

21-10-2015 • Senoo K and Lip GYH, Stroke 2015
Elderly patients are at high risk of CV death and stroke/systemic embolism, but age does not increase risk of any clinically relevant bleeding. High TTR negatively correlated with adverse outcomes. Read more

Pulse pressure may be useful in CV risk stratification

1-2-2016 • Selvaraj S et al., J Am Coll Cardiol 2016
High pulse pressure was associated with increased risk for CV death, MI, stroke, and CV hospitalisation, in subjects with established atherosclerosis or at risk, irrespective of mean arterial pressure. Read more
News • 26-1-2016

AHA review of evidence sex-specific characteristics of acute MI in women

CVD morbidity and mortality in women is higher than in men, but CHD remains underdiagnosed and undertreated in women. This statement reviews the available evidence on sex-specific characteristics and mechanisms of AMI in women. Read more

HFpEF patients benefit from dietary intervention and exercise

18-1-2016 • Kitzman DW et al., JAMA. 2016
A comprehensive caloric restriction and weight loss program with or without exercise training is beneficial for older and obese patients with heart failure with preserved ejection fraction. Read more

What to choose: ACE inhibitors or ARBs to lower CV risk?

13-1-2016 • Bangalore S et al., Mayo Clin Proc. 2016
While ACE inhibitors are associated with a mortality benefit, ARBs exhibit better tolerability, leading to higher adherence. This meta-analysis provides explanatory data that clarify outcome differences in older individual studies. Read more

CV benefit of BP-lowering seen also with low baseline BP and with varying comorbidities

7-1-2016 • Ettehad et al., The Lancet 2015
The beneficial effect of BP-lowering on various CV outcomes, also in individuals with lower baseline systolic BP, was broadly similar among populations with different comorbidities, in a large meta-analysis. Read more
News • 19-10-2015

German AFNET and EHRA lay out roadmap to improve AF management

Many people have undiagnosed and therefore untreated AF, associated with high risk of strokes and death. AFNET and EHRA composed recommendations aimed to improve AF diagnosis and treatment. Read more

Upcoming meetings

Meeting reports & resources

EPCCS Guidance Documents Evidence- and meeting-based guidance for primary care
EPCCS 2015 Report of 8th Annual EPCCS meeting held in Prague.
EPCCS 2014 Report of 7th Annual EPCCS meeting held in Brussels.
EPCCS 2013 Report of 6th Annual EPCCS meeting held in London
All meeting reports...