Reduced doses NOAC show similar efficacy and bleeding risk but possibly higher mortality risk
20-2-2017 • Nielsen PB et al., BMJ. 2017
Real-world data show lower dose NOACs associated with similar risk of thromboembolic events and similar or lower rates of bleeding as compared with warfarin in AF, but mortality risk seems higher with NOACs.
Functions of HDL particles better with Mediterranean diet
16-2-2017 • Hernáez Á, et al.
In a subgroup of PREDIMED study patients it was shown that a Mediterranean diet, especially the one enriched with olive oil, improved biological functions of HDL particles.
Severely elevated blood pressure predicts cognitive impairment
13-2-2017 • Muela HCS et al., JAHA 2017
New data show that cognitive impairment is more frequent in patients with more severe hypertension and that this severity is a good predictor for cognitive impairment.
Intervening on meal timing and frequency may be beneficial for cardiovascular disease prevention
7-2-2017 • St-Onge MP, et al, Circulation 2017
Irregular eating patterns appear less favourable for maintaining body weight and optimal cardiometabolic health.
News • 4-2-2017
PCSK9 inhibitor non-inferior to placebo for effect on cognitive function
The evolocumab EBBINGHAUS trial showed that the antibody against PCSK9 is non-inferior to placebo for the effect on cognitive function.
News • 2-2-2017
Less sodium consumption by 10% over 10 years cost effective in all nations
Sodium intake reduction of 10% over 10 years achieved by education, government and industry regulations was estimated to be most cost effective in all and extremely cost effective in nearly all of 183 nations evaluated.
Strict BP control did not improve or worsen gait speed in elderly SPRINT participants
20-2-2017 • Gilstrap LG et al., J Am Heart Assoc. 2017
No differences in gait speed decline or mobility limitations were seen in individuals of 75 years and older were seen between those receiving intensive BP-lowering therapy vs. standard therapy.
Healthy relatives of CAD patients have high coronary plaque burden
15-2-2017 • Christiansen MK et al. JACC Cardiol Img 2017
CT angiograms in 88 healthy relatives of patients with CAD onset before the age of 40, displayed high plaque burden and more unfavourable plaque features compared to controls.
Cholesterol levels in midlife predict Alzheimer disease with ASCVD
8-2-2017 • Rantanen K et al. Ann Med. 2017
After 49 years follow-up, the HBS study found that high cholesterol levels predict Alzheimer disease with atherosclerotic vascular disease (ASCVD), but not without ASCVD or with vascular dementia.
Intensive BP control in the elderly associated with decreased MACE but may increase risk of renal failure
In elderly hypertensive patients, intensive BP control decreased the risk of MACE, including CV mortality and HF, and increased the potential risk of renal failure.
News • 3-2-2017
Reduced CV event risk with PCSK9 inhibitor in CV outcomes study
Evolocumab FOURIER CV outcomes study meets primary and key secondary endpoints, showing reduced risk of CV events in those with ASCVD already on optimised statin therapy.
Depression and exhaustion as risk factor for CVD mortality
2-2-2017 • Ladwig KH, et al, Atherosclerosis, 2017
Depression and exhaustion predict lower life expectancy and higher CVD mortality risk with an effect size comparable to traditional major risk factors.
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